Short-course versus long-course oral antibiotic treatment for infections treated in outpatient settings: a review of systematic reviews

Abstract
Purpose

To summarize the evidence comparing the effectiveness of short and long courses of oral antibiotics for infections treated in outpatient settings.

Methods

We identified systematic reviews of randomized controlled trials for children and adults with bacterial infections treated in outpatient settings from Medline, Embase, CINAHL, Cochrane Database of Systematic Reviews and The Database of Review of Effects. Data were extracted on the primary outcome of clinical resolution and secondary outcomes.

Results

We identified 30 potential reviews, and included 9. There was no difference in the clinical cure for children treated with short or long course antibiotics for Group A streptococcal tonsillopharyngitis (OR 1.03, 95% CI:0.97, 1.11); community acquired pneumonia (RR 0.99, 95% CI:0.97, 1.01); acute otitis media [<2 years old OR: 1.09 (95% CI:0.76, 1.57); ≥2 years old OR: 0.85 (95% CI:0.60, 1.21)]; or urinary tract infection (RR 1.06, 95% CI:0.64, 1.76). There was no difference in the clinical cure for adults treated with short or long course antibiotics for acute bacterial sinusitis (RR 0.95, 95% CI:0.81, 1.21); uncomplicated cystitis in non-pregnant women (RR 1.10, 95% CI:0.96, 1.25), or elderly women (RR: 0.98, 95% CI:0.62, 1.54); acute pyelonephritis (RR 1.03, 95% CI:0.80, 1.32); or community acquired pneumonia (RR: 0.96, 95% CI:0.74, 1.26). We found inadequate evidence about the effect on antibiotic resistance.

Conclusions

This overview of systematic reviews has identified good quality evidence that short course antibiotics are as effective as longer courses for most common infections managed in ambulatory care. The impact on antibiotic resistance and associated treatment failure requires further study.






Related News

  • 3 Times It’s Okay&nbsp;to Be Rude
  • 5 ‘Nice’ Things You Do That Actually Annoy Restaurant Staff
  • Oprah Reveals Reese Witherspoon Showed Signs of PTSD After Harvey Weinstein Scandal Broke
  • 6 Sneaky Stress Triggers and What to Do About Them
  • The 6&nbsp;Essential Oil Mistakes You’re Probably Making
  • 14 Habits That Are Sabotaging Your Mental Health
  • Depression screening and management in primary care
  • I Was Sexually Assaulted in College.&nbsp;This Is How I Started Healing, and What I Do to Cope With Triggers in Today’s News Cycle
  • Leave a Reply

    Your email address will not be published. Required fields are marked as *

    *

    This blog is kept spam free by WP-SpamFree.

    %d bloggers like this: